Dds compound and method for measurement thereof

Details Dds compound and method for measurement thereof Dds compound and method for measurement thereof

C - Chemistry, Metallurgy

08

B

C08B 37/02 (2006.01) A61K 31/47 (2006.01) A61K 47/26 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2348931

A method for assaying a DDS compound containing a saccharide compound-modified carboxy C1-4 alkyldextran polyalcohol and a drug compound residue bonded to this carboxy C1-4 alkyldextran polyalcohol, or a DDS compound wherein a polymer carrier is bonded to a drug compound residue via a spacer containing 2 to 8 amino acids bonded together via peptide bonds, which involves the step of assaying a hydrolysate obtained by treating the DDS compound with peptidase.

Cette invention se rapporte à un procédé de dosage d'un composé DDS contenant un polyalcool d'alkyldextrane C¿1-4? carboxy modifié par un composé saccharide, ainsi qu'un résidu de composé médicamenteux lié à ce polyalcool d'alkyldextrane C¿1-4? carboxy, ou un composé DDS dans lequel un support polymère est lié à un résidu de composé médicamenteux par l'intermédiaire d'un élément d'espacement contenant 2 à 8 acides aminés liés entre eux par des liaisons peptides, ce procédé consistant à doser un hydrolysat que l'on obtient en traitant le composé DDS avec une peptidase.

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