Enzyme-cleavable prodrug compounds

Details Enzyme-cleavable prodrug compounds Enzyme-cleavable prodrug compounds

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2411660

The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavage sequences within the conjugate and methods of treating patients with prodrugs of the invention.

Ce promédicament est une forme modifiée d'un agent thérapeutique et comprend un agent thérapeutique, un oligopeptide, un groupe de stabilisation et éventuellement un groupe de liaison. Ce promédicament peut être clivé par la Thimet oligopeptidase, ou TOP. L'invention concerne également des procédés de conception de promédicaments comprenant l'introduction de séquences de clivage par TOP dans le conjugué, ainsi que des traitements comprenant l'administration des promédicaments décrits à des patients.

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