G protein coupled receptor

Details G protein coupled receptor G protein coupled receptor

G - Physics

01

N

G01N 33/74 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2587534

The present invention relates to the functional characterization of the G protein coupled receptor GPR39 and to compounds, which modify or regulate GPR39 protein activity. In particular the present invention relates to methods of screening for agonists or antagonists of GPR39 in order to identify compounds capable of modulating Gastrointestinal Kinetics and/or cholesterol metabolism and to the therapeutic uses of these compounds . The invention also relates to transgenic animals bearing mutations in the GPR39 gene.

La présente invention porte sur la caractérisation fonctionnelle du récepteur GPR39 couplé à la protéine G et sur des composés qui modifient ou régulent l'activité de la protéine GPR39. L'invention porte notamment sur des méthodes de recherche systématique des agonistes ou antagonistes de GPR39 afin d'identifier des composés capables de moduler la cinétique gastro-intestinale et/ou le métabolisme du cholestérol, l'invention portant également sur les utilisations thérapeutiques de ces composés. L'invention porte, en outre, sur des animaux transgéniques portant des mutations dans le gène GPR39.

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