C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/18 (2006.01) A61K 48/00 (2006.01) A61P 31/10 (2006.01) A61P 31/14 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2414017
Ataxia telangiectasia mutated (ATM)-dependent DNA damage signalling mechanisims are involved in retroviral and retrotransposon integration. Screening methods for inhibitors of retroviral and retrotranspons activity comprise inhibiting the ATM-dependent DNA damage signalling pathway, e.g. by disrupting interaction between components of the pathway. Inhibitors are useful as anti-retroviral agents, e.g. in inhibition of HIV.
Des mécanismes de signalisation des dommages à l'ADN dépendants de l'ataxia telangiectasia mutée (ATM) sont impliqués dans l'intégration rétrovirale et du rétrotransposon. Des méthodes de ciblage des inhibiteurs de l'activité rétrovirale et du rétrotransposon consiste à inhiber la voie de transmission de signalisation des dommages à l'ADN dépendants de l'ATM, par exemple par interruption de l'interaction entre des composés de la voie de transmission. On utilise les inhibiteurs comme des agents anti-rétroviraux, par exemple dans l'inhibition du VIH.
Jackson Stephen Philip
Lau Alan
O' Connor Mark James
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Kudos Pharmaceuticals Limited
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