A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61P 19/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2519131
Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.
L'invention concerne des compostions et des procédés liés à l'association spécifique imprévue de (i) la protéine sclérostine de liaison TGF-bêta avec la protéine chordine antagoniste BMP afin de former un complexe, et de (ii) la protéine sclérostine de liaison TGF-bêta avec la protéine noggine antagoniste BMP en vue de former un complexe, ni l'un ni l'autre ne pouvant se lier à un membre de la superfamille TGF-bêta telle qu'une BMP. L'invention concerne également des complexes isolés utilisés dans des dosage d'analyse en vue d'identifier des agents modifiant la minéralisation osseuse, et offrant d'autres avantages connexes.
Geoghegan James
Hayes Trenton
Latham John
Shpektor Diana
Skonier John
Celltech R. & D. Inc.
Gowling Lafleur Henderson Llp
Ucb Manufacturing Inc.
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