Macrocyclic inhibitors of hepatitis c virus

Details Macrocyclic inhibitors of hepatitis c virus Macrocyclic inhibitors of hepatitis c virus

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A61K 31/4709 (2006.01) A61P 31/14 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2616954

Inhibitors of HCV of formula (I), and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; and n is 3, 4, 5, or 6; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I) are provided. Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.

L'invention concerne des inhibiteurs du VHC de formule (I), ainsi que les N-oxydes, les sels, et les stéréoisomères de ces composés, la ligne pointillée représentant une éventuelle double liaison entre les atomes C7 et C8 ; R1 étant l'hydrogène ou un alkyle en C1-6 ; R2 étant l'hydrogène ou un alkyle en C1-6 ; et n valant 3, 4, 5, ou 6 ; des compositions pharmaceutiques contenant les composés (I) et des procédés de fabrication des composés (I). L'invention concerne également des mélanges biodisponibles des inhibiteurs du VHC de formule (I) avec du ritonavir.

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