B - Operations – Transporting – 81 – B
Patent
B - Operations, Transporting
81
B
B81B 1/00 (2006.01) G01N 27/447 (2006.01) G01P 5/20 (2006.01)
Patent
CA 2353998
Apparatus and methods for modulating flow rates in microfluidic devices are provided. The methods involve modulating downstream pressure in the device to change the flow rate of materials in an upstream region of the device. Such methods include electrokinetic injection or withdrawal of materials through a side channel and the use of an absorbent material to induce wicking in the channel system. The apparatus provided includes a prefabricated wick (350) in the device to provide for the flow rate control. Additional methods for determining velocity of a particle and cell incubation time are also provided.
La présente invention concerne un appareil et des procédés de modulation du débit dans des dispositifs microfluidiques. Ces procédés impliquent la modulation de la pression aval dans le dispositif permettant de modifier le débit des matières dans une région aval du dispositif. Ces procédés impliquent également l'injection électrocinétique ou le retrait des matières par un canal latéral, et l'utilisation d'une matière absorbante pour provoquer le drainage dans ce système de canaux. Par ailleurs, cet appareil comporte un drain préfabriqué (350) permettant de réguler le débit. Enfin, l'invention concerne d'autres procédés permettant de déterminer la vitesse d'une particule et le temps d'incubation des cellules.
Alajoki Marja Liisa
Dubrow Robert
Wada H. Garrett
Caliper Life Sciences Inc.
Caliper Technologies Corporation
Fetherstonhaugh & Co.
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