Method of inhibiting cancer growth

Details Method of inhibiting cancer growth Method of inhibiting cancer growth

A - Human Necessities

61

K

A61K 31/65 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2277865

The invention is a method of inhibiting cancer growth, by inhibiting cellular proliferation, invasiveness, or metastasis, or by inducing cytotoxicity against cancer in mammals. The method employs 6-demethyl-6-deoxy- 4-de(dimethylamino)tetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.

Cette invention concerne un procédé permettant d'inhiber le développement du cancer, lequel consiste à inhiber la prolifération cellulaire, le pouvoir envahissant ou la métastase ou, encore, à induire une cytotoxicité contre le cancer chez les mammifères. Afin d'inhiber le développement du cancer, on utilise de la 6-déméthyl-6-désoxy-4-dé(diméthylamino)tetracycline (CMT-3), ainsi que d'autres composés de tetracycline fonctionnellement apparentés qui ont été modifiés chimiquement et qui ne sont pas antibactériens de préférence. Ce procédé est particulièrement efficace afin d'inhiber l'établissement, la croissance et la métastase de tumeurs solides comme, par exemple, des tumeurs dérivées de cellules du cancer du colon, de cellules du cancer du sein, de cellules du mélanome, de cellules du carcinome de la prostate ou de cellules du cancer du poumon.

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