Mouse models carrying a knock-out mutation of the glutaminyl...

Details Mouse models carrying a knock-out mutation of the glutaminyl... Mouse models carrying a knock-out mutation of the glutaminyl...

C - Chemistry, Metallurgy

03

C

C03C 1/02 (2006.01) A01K 67/027 (2006.01) A61K 35/00 (2006.01) C03B 1/02 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2710494

The present invention provides a knock-out non-human animal, in particular a mouse carrying a glutaminyl cyclase (EC 2.3.2.5) knock-out mutation. The present invention additionally provides the respective cells and cell lines and methods and compositions for evaluating agents that affect Qpct, for use in compositions for the treatment of Qpct-related diseases.

La présente invention concerne un animal non-humain porteur d'un gène inactivé, en particulier, une souris porteuse d'une mutation du type inactivation du gène de la glutaminyl cyclase (EC 2.3.2.5). La présente invention concerne, en plus, les cellules et lignées cellulaires respectives ainsi que des procédés et des compositions pour évaluer des agents qui affectent le Qpct, destinés à être utilisés dans des compositions pour traiter les maladies liées au Qpct.

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