C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2440773
Novel compounds carrying ligands capable of ligating to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as in various methods. In particular, novel MHC molecule constructs comprising one or more MHC molecules are disclosed. The affinity and avidity of the MHC molecules of the constructs are surprisingly high. The possibility of presenting to the target cells a plurality of MHC molecules makes the MHC molecule constructs an extremely powerful tool e.g. in the field of diagnosis. The invention relates in general to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC molecules, MHC molecule multimers, and MHC molecule constructs.
L'invention concerne de nouveaux composés porteurs de ligands pouvant se lier à des contre-récepteurs sur des cellules cibles appropriées. Ces composés possèdent de nombreux avantages qui permettent de les utiliser dans diverses applications, notamment en tant que systèmes de détection, pour la détection de cellules cibles appropriées, ainsi que dans diverses méthodes. L'invention concerne en particulier de nouvelles constructions de molécules MHC comprenant une ou plusieurs molécules MHC. L'affinité et l'avidité des molécules MHC de ces constructions sont étonnamment élevées. La possibilité de présenter aux cellules cibles une pluralité de molécules MHC fait de ces constructions de molécules MHC un outil extrêmement puissant, p. ex. en matière de diagnostic. L'invention concerne en général le domaine de la thérapie, et notamment des méthodes et des compositions thérapeutiques. La présente invention concerne par ailleurs l'utilisation sur échantillon de molécules MHC, de multimères de molécules MHC et de constructions de molécules MHC.
Aamellem Oeystein
Buus Soeren
Petersen Lars Oestergaard
Ruud Erik
Schoeller Joergen
Dakocytomation Denmark A/s
Dynal Biotech Asa
Invitrogen Dynal As
Mbm Intellectual Property Law Llp
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