A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/57 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01) A61K 47/24 (2006.01) A61K 47/30 (2006.01)
Patent
CA 2228288
An O/W emulsion composition for eye drops comprising a medicine selected from among fluorometholone, clobetasone butyrate and clobetasol propionate, a phospholipid, liquid paraffin, and water. The composition is excellent in the solubility of fluorometholone, clobetasone butyrate and clobetasol propionate in the lacrimal fluid. Accordingly, it is expected to achieve in a small dose an anti-inflammatory activity comparable or superior to those of the conventional preparations, thus being excellent economically. It is also expected that fears of systemic side effects accompanying the intraocular administration of these medicines are relieved thereby.
Composition d'émulsion aqueuse pour collyres, renfermant un médicament qui peut être: du fluorométholone, du butyrate de clobétasone, du propionate de clobétasol, un phospholipide, une paraffine liquide et de l'eau. Cette composition assure une excellente solubilité du fluorométholone, du butyrate de clobétasone et du propionate de clobétasol dans le liquide lacrymal. Elle devrait donc, à faible dose, atteindre une activité anti-inflammatoire comparable ou supérieure à celle d'une préparation classique, et se révèle donc extrêmement économique. Elle devrait également parer aux craintes d'effets secondaires systémiques accompagnant l'administration intra-oculaire de ces médicaments.
Hirata Reiko
Maeda Makoto
Nagoshi Kaei
Naito Yoshikazu
Oguma Touru
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Wakamoto Pharmaceutical Co. Ltd.
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