C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 53/00 (2006.01) A61K 31/02 (2006.01) C07C 57/00 (2006.01) C12P 7/64 (2006.01)
Patent
CA 2588166
Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti- neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
Cette invention concerne des nouvelles oxylipines, intitulés, dans le descriptif, docosanoïdes, provenant des acides gras C22 polyinsaturés, ainsi que des procédés permettant de les fabriquer et de les utiliser. Cette invention concerne également l'utilisation d'acide docosapentaenoïque (C22:5n-6) (DPAn-6), d'acide docosapentaenoïque (C22:5n-3) (DPAn-3), et d'acide docosatetraenoïque (DTAn-6: C22:4n-6) en tant que substrats pour la production de nouvelles oxylipines, ainsi que les oxylipines produites selon ce mode de réalisation. L'invention concerne également l'utilisation de DPAn-6, DPAn-3, DTAn-6, et/ou des oxylipines provenant de ceux-ci, et/ou des nouveaux docosanoïdes provenant des structures des acides gras C22, dans des applications thérapeutiques, nutritionnelles ou cosmetiques, et tout particulièrement, en tant que composés anti-inflammatoires ou anti-neurogénérants. Cette invention concerne également des nouveaux modes de réalisation permettant de produire des huiles riches en acides polyinsaturés à longue chaîne (LCPUFA) et des compositions qui contiennent des quantités plus importantes et efficaces d'oxylipines provenant de LCPUFA, et particulièrement, les docosanoïdes.
Arterburn Linda Mary
Barclay William
Dangi Bindi
Flatt James
Lee Jung
Martek Biosciences Corporation
Mbm Intellectual Property Law Llp
LandOfFree
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