Penem derivatives

Details Penem derivatives Penem derivatives

C - Chemistry, Metallurgy

07

D

C07D 499/88 (2006.01) A61K 31/44 (2006.01) A61K 31/675 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2088913

2088913 9300345 PCTABS00019 The invention provides compounds of general formula (I) wherein R1 is a hydrogen atom, a negative charge or an ester residue; R is: a) -(CH2)n-A-CO2H, -(CH2)n-A-SO3H or -(CH2)n-A-PO3H2, wherein n is either zero, one or two and A is a group -CH=CH- (either E or Z), -OCH2-, -SCH2- or -CHOH-; b) -(CH2)n-PO3H2, -(CH2)nSO2NHCN, -(CH2)nNHSO3H, -(CH2)nCONHSO2CH3 or -(CH2)nCONHSO2CF3, wherein n is as defined above; c) -(CH2S)m-W-(CH2)nZ, wherein W is an arylene group or a heterocyclediyl group, m is 0 or 1, n is as above defined, and Z represents CO2H, PO3H2, SO2NHCN, NHSO3H, CONHSO2CH3 or CONHSO2CF3; d) -Y-CH2 formula (II), wherein Y is O or NH and X is NH, N-OH or N-O-(CH2)n+1COOH wherein n is as defined above; or e) -(CH2S)m-W', wherein W' is a heterocyclyl group convertible into an anion at physiological pH and m is as defined above. Compounds (I), their salts and ester prodrugs have antibacterial activity.

Affiliated with

Also associated with

Rating

Penem derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Penem derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Penem derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2072386