Pharmaceutical compositions in particulate form

Details Pharmaceutical compositions in particulate form Pharmaceutical compositions in particulate form

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/19 (2006.01) A61K 9/22 (2006.01) A61K 38/28 (2006.01) A61K 39/145 (2006.01)

Patent

CA 2466982

A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35µ and about 300µ, and/or the powder comprises dried particles having an average mean diameter of between about 35µ and about 300µ. Compositions made by the above methods, and methods of using the compositions, are also described.

L'invention concerne un procédé permettant de préparer une composition pharmaceutique. Ledit procédé consiste 1) à atomiser une formulation liquide d'un agent thérapeutique afin de former une formulation atomisée; 2) à congeler la formulation atomisée afin de former des particules solides; et 3) à sécher les particules solides à une pression sensiblement atmosphérique afin de produire une poudre, le séchage étant effectué à l'aide de vibrations, d'éléments internes, d'agitation mécanique, ou d'une combinaison de ceux-ci. Un autre procédé consiste 1) à atomiser une formulation liquide d'un agent thérapeutique afin de former une formulation atomisée; 2) à congeler la formulation atomisée afin de former des particules solides; et 3) ) à sécher les particules solides afin de produire une poudre. La formulation atomisée comprend des gouttelettes de diamètre moyen compris entre 35µ et 300µ, et/ou la poudre comprend des particules séchées de diamètre moyen compris entre 35µ et 300µ. L'invention concerne également les compositions préparées à partir des procédés précités et des procédés utilisant lesdites compositions.

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