Pharmaceutically active sulfonyl amino acid derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 409/12 (2006.01) A61K 31/18 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) C07C 213/00 (2006.01) C07C 311/46 (2006.01) C07C 333/00 (2006.01) C07C 409/12 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2384997

The present invention is related to sulfonyl amino acid derivatives of formula (I), notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl amino acid derivatives. Said sulfonyl amino acid are efficient modulators of the JNK pathway, they are in particular efficient inhibitors of JNK 2 and 33. The present invention is furthermore related to novel sulfonyl amino acid derivatives as well as to methods of their preparation.

La présente invention concerne des dérivés d'acides aminés sulfonyle de la formule (I) destinés notamment à être utilisés en tant que composés pharmaceutiques actifs, ainsi que des formulations pharmaceutiques contenant ces dérivés d'acides aminés sulfonyle. Lesdits acides aminés sulfonyle sont d'efficaces modulateurs de la voie JNK, ils sont notamment d'efficaces inhibiteurs de JNK 2 et 33. La présente invention concerne également de nouveaux dérivés d'acides aminés sulfonyle ainsi que des méthodes permettant leur préparation.

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