C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4245 (2006.01) A61K 31/444 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 403/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 491/056 (2006.01)
Patent
CA 2694860
Disclosed are the ERK inhibitors of formula 1.0: (Chemical formula should be inserted here as it appears on abstract in paper form) and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1Ø
L'invention concerne des inhibiteurs ERK de la formule 1.0: (La formule chimique devrait être insérée ici comme elle apparaît sur l'abrégé sous forme papier) et des sels pharmaceutiquement acceptables, des esters et des solvates de ceux-ci. Q est un cycle de pipéridine ou de pipérazine qui peut avoir un pont ou un cycle fusionné. Le cycle de pipéridine peut avoir une double liaison dans le cycle. Tous autres substituants sont tels que définis ci-dessus. Des procédés de traitement du cancer utilisant les composés de la formule 1.0 sont également décrits.
Alhassan Abdul-Basit
Boga Sobhana Babu
Cooper Alan
Deng Yongqi
Desai Jagdish
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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