C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/240, 260/319
C07D 209/42 (2006.01) A61K 31/405 (2006.01) E04B 1/32 (2006.01)
Patent
CA 2008911
A process for preparing a novel compound - ethyl 6-bromo-5- hydroxy-4-dimethylaminomethyl-1-methyl-2-phenyl-thiomethyl- 3-carboxylate hydrochloride monohydrate of the following formula: Image involves treating ethyl 5-acetoxy-1,2-dimethylindole-3-car- boxylate with a brominating agent in an inert organic sol- vent under reflux, reacting the resultant ethyl 5-acetoxy-6- bromo-2-bromomethyl-1-methylindole-3-carboxylate to react with thiophenol in the presence of an alkali metal hydroxide or its alcoholate in an organic solvent, reacting the resultant ethyl 6-bromo-5-hydroxy-1-methyl-2-phenyl- thiomethylindole-3-carboxylate with an aminomethylating agent in an organic solvent at a temperature from 65° to a temperature of refluxing the reaction mixture. The end product is then isolated from the resultant base-ethyl 6- bromo-5-hydroxy-4-dimethylaminomethyl-1-2-phenylthiomet- hylindole-3-carboxylate. The compound according to the invention is an active principle of a pharmaceutical preparation having the antiviral, immunomodulatory and inerferon-inducing effect.
Bogdanova Nadezhda S.
Bryantseva Elena A.
Fomina Alla N.
Grinev Alexei Nikolaevich
Karpova Nina A.
Leningradsky Nauchno-Issledovatelsky Institut Epidemiologii I. M
Marks & Clerk
Nauchno-Issledovatelsky Institut Meditsinskoi Radiologii Akademi
Vsesojuzny Nauchno-Issledovatelsky Khimiko-Farmatsevtichesky Ins
LandOfFree
Process for preparing ethyl 6-bromo-5-hydroxy-4-... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparing ethyl 6-bromo-5-hydroxy-4-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing ethyl 6-bromo-5-hydroxy-4-... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1991746