Substituted biaryl amides as c5a receptor modulators

Details Substituted biaryl amides as c5a receptor modulators Substituted biaryl amides as c5a receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 409/12 (2006.01) A61K 31/357 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) C07C 233/65 (2006.01) C07C 235/62 (2006.01) C07D 207/327 (2006.01) C07D 209/08 (2006.01) C07D 215/00 (2006.01) C07D 231/56 (2006.01) C07D 233/02 (2006.01) C07D 235/02 (2006.01) C07D 235/06 (2006.01) C07D 317/44 (2006.01) C07D 317/58 (2006.01) C07D 333/24 (2006.01) C07D 405/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2479928

Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des biarylamides substitués de formule (I) qui sont des ligands que l'on peut utiliser pour moduler l'activité du récepteur C5a <i>in vivo</i> ou <i>in vitro</i> et conviennent particulièrement dans le traitement de pathologies associées à l'activation du récepteur C5a pathologique chez les humains, les animaux domestiques et le bétail. Font également l'objet de cette invention des compositions pharmaceutiques et leurs procédés d'utilisation dans le traitement de tels troubles, notamment les procédés d'utilisation de tels ligands en vue d'analyses de localisation du récepteur.

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