C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/60 (2006.01) A61K 31/195 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07C 323/60 (2006.01) C07C 323/62 (2006.01) C07D 263/26 (2006.01)
Patent
CA 2376094
The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor a (PPAR.alpha.), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride). It relates to substituted phenylpropanoic acid derivatives represented by a general formula (1), (see formula 1) their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.
L'invention concerne de nouveaux dérivés d'acide phénylpropionique substitués capables de se lier comme un ligand à un récepteur humain activé de la prolifération des peroxysomes alpha (PPAR alpha ) pour activer le récepteur, ces dérivés exerçant donc un effet puissant de réduction des niveaux de lipides sanguins (cholestérol et lipides neutres). L'invention a donc trait à des dérivés d'acide phénylpropionique substitués représentés par la formule générale (1), leurs sels et hydrates acceptables du point de vue pharmaceutique, ainsi que leur procédé de production.
Ide Tomohiro
Miyachi Hiroyuki
Murakami Koji
Nomura Masahiro
Takahashi Yukie
Borden Ladner Gervais Llp
Kyorin Pharmaceutical Co. Ltd.
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