A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 31/135 (2006.01) A61K 47/30 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2644750
The present invention relates to a rasagiline transdermal patch for treatment or prophylaxis of nervous system diseases, in which the patch comprises an inert backing layer chemically inert to substrate ingredients, a substrate layer comprising rasagiline or a pharmaceutically acceptable salt thereof, and a protective layer to be peeled off before use. The substrate layer is an adhesive system comprising an organic polymer material as basis and an inorganic or organic material as filler, and a plurality of micro-reservoirs containing rasagiline. The substrate further comprises one or more substances for enhancing the transdermal absorption of rasagiline, in which the above organic polymer material in the substrate is used for the reservoir of rasagiline and as adhesive.
L'invention concerne un timbre transdermique contenant de la rasagiline, utilisé dans le traitement ou la prévention de maladies du système nerveux, ainsi qu'un procédé de préparation associé. Le timbre selon l'invention comprend : une couche de support inerte pour les composants de la matrice, une couche matrice contenant de la rasagiline et/ou un de ses sels, et une couche de protection amovible. Ce timbre se caractérise en ce que la matrice est un système adhésif contenant un polymère et un agent gonflant organique ou inorganique ainsi qu'un activateur de pénétration dermique, que le réservoir de la couche matrice contient de la rasagiline, et que le polymère est dérivé d'un matériau macromoléculaire organique et sert de principe actif au réservoir et à l'adhésif.
Deng Jie
Lin Jialiang
Xiao Jinmai
Chongqing Pharmaceutical Research Institute Co. Ltd.
Osler Hoskin & Harcourt Llp
Shanghai Fosun Pharmaceutical (group) Co. Ltd.
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