C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 267/02 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07D 209/02 (2006.01) C07D 209/96 (2006.01) C07D 211/02 (2006.01) C07D 215/02 (2006.01) C07D 403/02 (2006.01) C07D 413/02 (2006.01) C07D 451/02 (2006.01)
Patent
CA 2494962
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non- receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
La présente invention concerne des composés capables d'inhiber, de moduler et/ou de réguler la transduction de signal à la fois des tyrosine kinases de type récepteur et de type non-récepteur. Ces composés présentent une structure principale comprenant un groupe fonctionnel sulfonyl indole. La présente invention concerne également des sels pharmaceutiquement acceptables, des hydrates et des stéréoisomères de ces composés.
Bergman Jeffrey M.
Beshore Douglas C.
Dinsmore Christopher J.
Lindsley Craig W.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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