Ultra high affinity neutralizing antibodies

Details Ultra high affinity neutralizing antibodies Ultra high affinity neutralizing antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/42 (2006.01) A61P 31/12 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2398466

Ultra high affinity antibodies with binding affinities in the range of 1010M- 1, and even 1011 M-1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.

L'invention concerne des anticorps d'affinité ultra-élevée possédant des affinités de liaison de l'ordre de 10?10¿ M?-1¿, voire même de 10?11¿ M?-1¿. Lesdits anticorps sont, entre autres, des anticorps possédant des nouvelles régions complémentaires déterminant une complémentarité d'affinité élevée, notamment des régions dont l'infrastructure et les régions constantes sont dérivées d'humains ou de souris. L'invention porte également sur des méthodes de préparation et de criblage desdits anticorps, ainsi que sur leurs procédés d'utilisation pour prévenir et/ou traiter des maladies, telles que les malades induites par un virus.

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