Use of a hyperpolarized gas for mri detection of regional...

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G01R 33/28 (2006.01) A61B 5/055 (2006.01)

Patent

CA 2327733

The invention provides a method of detecting regional variations in oxygen uptake from the lungs of an air-breathing animal subject, said method comprising administering into the lungs of said subject a diagnostically effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, detecting the magnetic resonance signal from said agent in said lungs, determining the temporal variation in relaxation rate for said signal for at least one region of interest whitin said lungs, and from said variation generating a qualitative or quantitative value or image indicative of the oygen concentration in at least one region of interest, and if desired the time dependency of such concentration.

L'invention concerne un procédé permettant de détecter les variations de consommation d'oxygène entre les différentes régions des poumons d'un sujet animal respirant de l'air. Ce procédé consiste à administrer dans les poumons de ce sujet une quantité efficace à titre diagnostique d'un agent gazeux hyperpolarisé d'imagerie par résonance magnétique, puis à détecter le signal de résonance magnétique de cet agent dans les poumons, pour ensuite calculer la variation temporelle de la vitesse de relaxation de ce signal dans au moins une région d'intérêt à l'intérieur des poumons. On peut alors calculer, à partir de cette variation, une valeur ou une image qualitative ou quantitative indiquant la concentration d'oxygène dans une moins une région d'intérêt, et le cas échéant, la distribution temporelle de cette concentration.

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