Use of indole derivatives for the treatment of various diseases

A - Human Necessities – 61 – K

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A61K 31/40 (2006.01) A61K 31/404 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2202484

The invention provides the use of a compound of formula (I) wherein R1 and R2 independently represent H or C1-C6 alkyl, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of: dermatological disorders; peripheral neuropathies; arthritis; gastrointestinal or urogenital diseases; headache associated with substances or their withdrawal; tension headache; pediatric migraine; post-traumatic dysautonomic cephalgia; orofacial pain; allergic or chronic obstructive airways diseases; glaucoma or ocular inflammation; or prophylaxis of migraine.

On décrit l'utilisation d'un composé de la formule (I) ou un sel de celui-ci acceptable sur le plan pharmacologique, formule dans laquelle R<1> et R<2> représentent indépendamment H ou alkyle C1-C6. On utilise ce composé dans la fabrication d'un médicament destiné à traiter des affections dermatologiques, des neuropathies périphériques, l'arthrite, des maladies gastro-intestinales ou génito-urinaires, des céphalées associées à la prise de substances ou à la privation de celles-ci, des céphalées par tension nerveuse, la migraine infantile, des céphalalgies dysautonomiques post-traumatiques, des douleurs bucco-faciales, des syndromes respiratoires obstructifs, allergiques ou chroniques, le glaucome ou l'inflammation oculaire; ce médicament est également destiné à la prophylaxie de la migraine.

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