C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 35/00 (2006.01) C07K 14/285 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2674552
The present invention relates to fusion proteins comprising an antigen derived from the so-called tumour rejection antigen PRAME (also known as DAGE) linked to an immunological fusion partner which provides T helper epitopes, such as, for example protein D from Haemophilus influenzae B, fusion partner proteins comprising fragments of protein D, methods for preparing the same and for formulating vaccines and use of the same for treating a range of cancers.
La présente invention concerne des protéines de fusion comprenant un antigène dérivé de l'antigène dit de rejet des tumeurs PRAME (également nommé DAGE) lié à un partenaire de fusion immunologique qui fournit des épitopes de lymphocytes T auxiliaires, tels que, par exemple, la protéine D de Haemophilus influenzae B, des protéines partenaires de fusion comprenant des fragments de la protéine D, des procédés pour leur préparation et la formulation de vaccins ainsi que leur utilisation dans le traitement de tout un éventail de cancers.
Blais Normand
Martin Denis
Palmantier Remi M.
Glaxosmithkline Biologicals S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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