Xanthones, thioxanthones and acridinones as dna-pk inhibitors

Details Xanthones, thioxanthones and acridinones as dna-pk inhibitors Xanthones, thioxanthones and acridinones as dna-pk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 311/86 (2006.01) A61K 31/35 (2006.01) A61P 35/00 (2006.01) C07D 219/06 (2006.01) C07D 219/16 (2006.01) C07D 221/00 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01) C07F 9/64 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2523178

Compound that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods of inhibiting the DNA-PK biological activity, methods of sensitizing cells the agents that cause DNA lesions, and methods of potentiating cancer treatment are disclosed.

L'invention porte sur des composés qui inhibent la protéine kinase dépendant de l'ADN, sur des compositions comprenant lesdits composés, sur des procédés d'inhibition de l'activité biologique d'ADN-PK, sur des procédés de sensibilisation des cellules, sur les agents qui provoquent les lésions de l'ADN et sur des procédés de potentialisation d'un traitement anticancéreux.

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