C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/08 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) A61P 35/02 (2006.01) A61P 37/02 (2006.01) C07K 1/02 (2006.01) C07K 14/535 (2006.01)
Patent
CA 2710841
The present invention relates to granulocyte colony stimulating factor (G-CSF) modified with Y-shaped branched polyethylene glycol (YPEG-G-CSF) at a specific lysine (Lys 17) and the preparation thereof, as well as the pharmaceutical composition comprising YPEG-G-CSF and use thereof.
La présente invention concerne le facteur stimulant la formation de colonies de granulocytes (G-CSF) mono-modifié par du polyéthylène glycol à ramification de type Y sur la position spécifique de la lysine (Lys17) et sa méthode de préparation. Le G-CSF PEGylé peut être utilisé pour la fabrication d'une composition pharmaceutique destinée à traiter une neutropénie induite par une infection, une leucémie et une chimiothérapie, entre autres.
Cai Huili
Chen Ping
Deng Hongyuan
He Yan
Huang Shuying
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biosteed Gene Expression Tech. Co. Ltd.
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