Hybrid digital and channel microfluidic devices and methods...

B - Operations – Transporting – 81 – B

Patent

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Details

B81B 7/04 (2006.01) B81C 3/00 (2006.01) G01N 1/00 (2006.01) G01N 27/447 (2006.01)

Patent

CA 2740113

The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated struc-ture in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hy-brid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet trans-ported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital mi-crofluidic device.

La présente invention concerne un dispositif microfluidique hybride numérique et à canal sous la forme d'une structure intégrée, une gouttelette pouvant être transportée par un réseau microfluidique numérique et transférée à un canal microfluidique. Selon un aspect de l'invention, un dispositif hybride comprend un premier substrat ayant un réseau microfluidique numérique qui peut transporter une gouttelette jusqu'à un emplacement de transfert, et un second substrat ayant un canal microfluidique. Les premier et second substrats sont fixés de manière à former un dispositif hybride, une ouverture dans le canal microfluidique étant positionnée de façon adjacente à l'emplacement de transfert de telle sorte qu'une gouttelette transportée jusqu'à l'emplacement de transfert entre en contact avec l'ouverture de canal et puisse entrer dans le canal. L'invention concerne également des procédés d'exécution de séparations à l'aide d'un dispositif microfluidique hybride numérique et à canal et des procédés d'assemblage d'un dispositif microfluidique hybride numérique.

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