Ligands for tgf-beta binding proteins and uses thereof

Details Ligands for tgf-beta binding proteins and uses thereof Ligands for tgf-beta binding proteins and uses thereof

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61P 19/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2519131

Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.

L'invention concerne des compostions et des procédés liés à l'association spécifique imprévue de (i) la protéine sclérostine de liaison TGF-bêta avec la protéine chordine antagoniste BMP afin de former un complexe, et de (ii) la protéine sclérostine de liaison TGF-bêta avec la protéine noggine antagoniste BMP en vue de former un complexe, ni l'un ni l'autre ne pouvant se lier à un membre de la superfamille TGF-bêta telle qu'une BMP. L'invention concerne également des complexes isolés utilisés dans des dosage d'analyse en vue d'identifier des agents modifiant la minéralisation osseuse, et offrant d'autres avantages connexes.

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