C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61P 31/18 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2667551
The present invention describes the synthesis of the compounds of formulae (1), (2) and (3) in which m and n, which may be identical or different, may have the values 0, 2, 3, 4, 5 and 6; Z and Y, which may be identical or different, represent a nitrogenated cyclic system bonded by nitrogen or by one of the carbon rings or an NR1R2 system; and X is selected from the group formed by hydrogen, C1-C12 alkyl, substituted alkyl, C3-C12 aryl, amino, alkylamino, nitro, hydroxy, alkoxy, halogen, carboxy or carboxamido. The use of the compounds of formulae (1), (2) and (3) as anti-HIV agents in the treatment of Acquired Immune Deficiency Syndrome (AIDS) is described.
La présente invention concerne la synthèse de composés représentés par les formules (1), (2) et (3) dans lesquelles m et n, qui peuvent être identiques ou différents, peuvent valoir 0, 2, 3, 4, 5 et 6; Z et Y, qui peuvent être identiques ou différents, représentent un système cyclique azoté lié par l'azote ou par un des carbones annulaires ou un système NR1R2; et X est sélectionné dans le groupe comprenant hydrogène, alkyle C1-C12, alkyle substitué, aryle C3-C12, amino, alkylamino, nitro, hydroxy, alcoxy, halogène, carboxy ou carboxamido. L'invention concerne également l'utilisation des composés représentés par les formules 1), (2) et (3) en tant qu'agents anti-VIH dans le traitement du syndrome d'immunodéficience aquise (SIDA).
Armand Ugon Mercedes
Batllori Aguila Xavier
Borrell Bilbao Jose Ignacio
Clotet Codina Imma
Este Araque Jose
Fetherstonhaugh & Co.
Institut Quimic de Sarria Cets
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